Sex- and Strain-dependent Effects of Bisphenol: A Consumption in Juvenile Mice

Children are directly exposed to bisphenol A (BPA) and other putative environmental obesogens through both diet and household products. The purpose of this study was to investigate sexand genetic-dependent effects of BPA consumption on traits relevant to obesity and Type 2 diabetes in juveniles, using mice as models. Two strains of mice (C57BL/6J and DBA/2J) were chosen to represent distinct genetic backgrounds that differ in susceptibility to obesity and insulin resistance. Male and female mice of each strain consumed BPA at three doses in drinking water from four to eleven weeks of age. Male but not female mice of each strain consuming BPA were significantly fatter than controls. BPA induced corresponding changes in adipose tissue gene expression and metabolite abundance that indicate effects on adipogenesis and energy utilization. BPA consumption also altered the synthesis of adipokines, circulating factors that modulate insulin sensitivity and atherogenesis, in C57BL/6J but not DBA/2J males. Conversely, effects of BPA on plasma insulin were only observed in female mice, and with opposite effects in the two strains. These results suggest that dietary BPA may exacerbate childhood obesity and its consequences, and that sex and genetic background are important determinants of the physiological impact of BPA. Sexand Strain-dependent Effects of Bisphenol: A Consumption in Juvenile Mice Brantley S Wyatt1, Jessica R Gooding2, Suchita Das1, Shawn R Campagna2, Arnold M Saxton1, Stephen Dearth2 and Brynn H Voy1* 1Department of Animal Science, University of Tennessee, Knoxville TN, 37996, USA 2Department of Chemistry, University of Tennessee, Knoxville TN, 37996, USA *Corresponding author: Brynn H Voy, Department of Animal Science, University of Tennessee, Knoxville TN, 37996, USA, Tel: (865)974-4790; E-mail: [email protected] Received July 26, 2016; Accepted August 08, 2016; Published August 15, 2016 Citation: Wyatt BS, Gooding JR, Das S, Campagna SR, Saxton AM, et al. (2016) Sexand Strain-dependent Effects of Bisphenol: A Consumption in Juvenile Mice. J Diabetes Metab 7: 694. doi: 10.4172/2155-6156.1000694 Copyright: © 2016 Wyatt BS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.